The cardiometabolic consequences of replacing saturated fats with carbohydrates or Ω-6 polyunsaturated fats: Do the dietary guidelines have it wrong?

The cardiometabolic consequences of replacing saturated fats with carbohydrates or Ω-6 polyunsaturated fats: Do the dietary guidelines have it wrong?

HISTORY OF THE LOW-FAT ‘DIET-HEART’ HYPOTHESIS The vilification of saturated fat by Keys began two decades before the seven countries study, where Keys showed a curvilinear association between fat calories as a percentage of total calories and death from degenerative heart disease from six countries. However, he excluded data from 16 countries that did not fit his hypothesis. Indeed, data were ...

Table. Reviews of Randomized Controlled Trials on Replacing Saturated Fats With Polyunsaturated Fats Publication RCTs of PUFAs for SFA

Saturated fats

The Heart of Mersey cardiovascular disease prevention programme in the UK Launched in 2003, following a visit to Finland, the Heart of Mersey (HoM) cardiovascular disease (CVD) prevention programme aims to improve the health of the local population through structural changes at regional, national and European level.(1) Based on the evidence (ie raised blood cholesterol and blood pressure, and t...

Changes in rabbit lipoprotein properties by dietary cholesterol, and saturated and polyunsaturated fats.

Plasma lipids and chemical, electrophoretic and electron microscopic properties of VLDL, LDL and HDL are examined in rabbits fed a control diet (group I) or diets containing 1% cholesterol (group II), 1% cholesterol + 5% coconut oil (group III) or 1% cholesterol + 5% corn oil (group IV). The diets II, III and IV resulted in hypercholesterolemia, hypertriglyceridemia and hyperphospholipidemia. T...

Balanced Diets Include Carbohydrates, Proteins, and Fats

In addition to the steep voltage-dependent K 1 currents that play a role in repolarization of the heart, two major K conductances control the resting potential. The classical strong inward rectifier (IK1) is constitutively active and acts to stabilize the resting potential. During depolarization, the strong rectification of IK1 significantly reduces conductance, permitting a long action-potenti...